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Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2015, 87, 1, 394-398
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Tattoo-Based Noninvasive Glucose Monitoring: A Proof-of-Concept Study

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Department of NanoEngineering, University of California, San Diego, La Jolla, California 92093, United States
*E-mail: [email protected]. Fax: +1 (858) 534 9553. Phone: +1 (858) 246 0128.
Cite this: Anal. Chem. 2015, 87, 1, 394–398
Publication Date (Web):December 12, 2014
https://doi.org/10.1021/ac504300n
Copyright © 2014 American Chemical Society
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Abstract

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We present a proof-of-concept demonstration of an all-printed temporary tattoo-based glucose sensor for noninvasive glycemic monitoring. The sensor represents the first example of an easy-to-wear flexible tattoo-based epidermal diagnostic device combining reverse iontophoretic extraction of interstitial glucose and an enzyme-based amperometric biosensor. In-vitro studies reveal the tattoo sensor’s linear response toward physiologically relevant glucose levels with negligible interferences from common coexisting electroactive species. The iontophoretic-biosensing tattoo platform is reduced to practice by applying the device on human subjects and monitoring variations in glycemic levels due to food consumption. Correlation of the sensor response with that of a commercial glucose meter underscores the promise of the tattoo sensor to detect glucose levels in a noninvasive fashion. Control on-body experiments demonstrate the importance of the reverse iontophoresis operation and validate the sensor specificity. This preliminary investigation indicates that the tattoo-based iontophoresis-sensor platform holds considerable promise for efficient diabetes management and can be extended toward noninvasive monitoring of other physiologically relevant analytes present in the interstitial fluid.

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Plot depicting blood glucose levels measured for two subjects before and after meal consumption. This material is available free of charge via the Internet at http://pubs.acs.org.

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