Behaviorally Assessed Sleep and Susceptibility to the Common Cold
- PMID: 26118561
- PMCID: PMC4531403
- DOI: 10.5665/sleep.4968
Behaviorally Assessed Sleep and Susceptibility to the Common Cold
Abstract
Study objectives: Short sleep duration and poor sleep continuity have been implicated in the susceptibility to infectious illness. However, prior research has relied on subjective measures of sleep, which are subject to recall bias. The aim of this study was to determine whether sleep, measured behaviorally using wrist actigraphy, predicted cold incidence following experimental viral exposure.
Design, measurements, and results: A total of 164 healthy men and women (age range, 18 to 55 y) volunteered for this study. Wrist actigraphy and sleep diaries assessed sleep duration and sleep continuity over 7 consecutive days. Participants were then quarantined and administered nasal drops containing the rhinovirus, and monitored over 5 days for the development of a clinical cold (defined by infection in the presence of objective signs of illness). Logistic regression analysis revealed that actigraphy- assessed shorter sleep duration was associated with an increased likelihood of development of a clinical cold. Specifically, those sleeping < 5 h (odds ratio [OR] = 4.50, 95% confidence interval [CI], 1.08-18.69) or sleeping between 5 to 6 h (OR = 4.24, 95% CI, 1.08-16.71) were at greater risk of developing the cold compared to those sleeping > 7 h per night; those sleeping 6.01 to 7 h were at no greater risk (OR = 1.66; 95% CI 0.40-6.95). This association was independent of prechallenge antibody levels, demographics, season of the year, body mass index, psychological variables, and health practices. Sleep fragmentation was unrelated to cold susceptibility. Other sleep variables obtained using diary and actigraphy were not strong predictors of cold susceptibility.
Conclusions: Shorter sleep duration, measured behaviorally using actigraphy prior to viral exposure, was associated with increased susceptibility to the common cold.
Keywords: common cold; immunity; rhinovirus; sleep continuity; sleep duration.
© 2015 Associated Professional Sleep Societies, LLC.
Figures
Comment in
-
Sleep, Don't Sneeze: Longer Sleep Reduces the Risk of Catching a Cold.Sleep. 2015 Sep 1;38(9):1341-2. doi: 10.5665/sleep.4958. Sleep. 2015. PMID: 26285007 Free PMC article. No abstract available.
Similar articles
-
Sleep habits and susceptibility to the common cold.Arch Intern Med. 2009 Jan 12;169(1):62-7. doi: 10.1001/archinternmed.2008.505. Arch Intern Med. 2009. PMID: 19139325 Free PMC article.
-
Self-Rated Health in Healthy Adults and Susceptibility to the Common Cold.Psychosom Med. 2015 Nov-Dec;77(9):959-68. doi: 10.1097/PSY.0000000000000232. Psychosom Med. 2015. PMID: 26397938 Free PMC article.
-
Parenthood and host resistance to the common cold.Psychosom Med. 2012 Jul-Aug;74(6):567-73. doi: 10.1097/PSY.0b013e31825941ff. Psychosom Med. 2012. PMID: 22773866 Free PMC article.
-
Has adult sleep duration declined over the last 50+ years?Sleep Med Rev. 2016 Aug;28:69-85. doi: 10.1016/j.smrv.2015.08.004. Epub 2015 Aug 28. Sleep Med Rev. 2016. PMID: 26478985 Free PMC article. Review.
-
The influence of signal variation, bias, noise and effect size on statistical significance in treatment studies of the common cold.Antiviral Res. 1996 Mar;29(2-3):287-95. doi: 10.1016/0166-3542(95)00935-3. Antiviral Res. 1996. PMID: 8739607 Review.
Cited by 81 articles
-
Respiratory Viral Infections in Athletes: Many Unanswered Questions.Sports Med. 2022 Mar 30:1-9. doi: 10.1007/s40279-022-01660-9. Online ahead of print. Sports Med. 2022. PMID: 35353361 Free PMC article.
-
The Importance of Sleep and Circadian Rhythms for Vaccination Success and Susceptibility to Viral Infections.Clocks Sleep. 2022 Feb 16;4(1):66-79. doi: 10.3390/clockssleep4010008. Clocks Sleep. 2022. PMID: 35225954 Free PMC article. Review.
-
The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections.medRxiv. 2022 Feb 17:2022.02.16.22271055. doi: 10.1101/2022.02.16.22271055. Preprint. medRxiv. 2022. PMID: 35194621 Free PMC article.
-
Subjective sleep quality before and during the COVID-19 pandemic in a Brazilian rural population.Sleep Health. 2021 Dec 16;8(2):673. doi: 10.1016/j.sleh.2021.11.007. Online ahead of print. Sleep Health. 2021. PMID: 34924345 Free PMC article.
-
Role of sleep deprivation in immune-related disease risk and outcomes.Commun Biol. 2021 Nov 18;4(1):1304. doi: 10.1038/s42003-021-02825-4. Commun Biol. 2021. PMID: 34795404 Free PMC article. Review.
Publication types
MeSH terms
Grant support
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical