Multivitamin-mineral use is associated with reduced risk of cardiovascular disease mortality among women in the United States
- PMID: 25733474
- PMCID: PMC4336535
- DOI: 10.3945/jn.114.204743
Multivitamin-mineral use is associated with reduced risk of cardiovascular disease mortality among women in the United States
Abstract
Background: Multivitamin-mineral (MVM) products are the most commonly used supplements in the United States, followed by multivitamin (MV) products. Two randomized clinical trials (RCTs) did not show an effect of MVMs or MVs on cardiovascular disease (CVD) mortality; however, no clinical trial data are available for women with MVM supplement use and CVD mortality.
Objective: The objective of this research was to examine the association between MVM and MV use and CVD-specific mortality among US adults without CVD.
Methods: A nationally representative sample of adults from the restricted data NHANES III (1988-1994; n = 8678; age ≥40 y) were matched with mortality data reported by the National Death Index through 2011 to examine associations between MVM and MV use and CVD mortality by using Cox proportional hazards models, adjusting for multiple potential confounders.
Results: We observed no significant association between CVD mortality and users of MVMs or MVs compared with nonusers; however, when users were classified by the reported length of time products were used, a significant association was found with MVM use of >3 y compared with nonusers (HR: 0.65; 95% CI: 0.49, 0.85). This finding was largely driven by the significant association among women (HR: 0.56; 95% CI: 0.37, 0.85) but not men (HR: 0.79; 95% CI: 0.44, 1.42). No significant association was observed for MV products and CVD mortality in fully adjusted models.
Conclusions: In this nationally representative data set with detailed information on supplement use and CVD mortality data ∼20 y later, we found an association between MVM use of >3 y and reduced CVD mortality risk for women when models controlled for age, race, education, body mass index, alcohol, aspirin use, serum lipids, blood pressure, and blood glucose/glycated hemoglobin. Our results are consistent with the 1 available RCT in men, indicating no relation with MVM use and CVD mortality.
Keywords: NHANES; cardiovascular disease; dietary supplement; mortality; multivitamin-mineral.
© 2015 American Society for Nutrition.
Conflict of interest statement
Author disclosures: RL Bailey, TH Fakhouri, Y Park, JT Dwyer, PR Thomas, JJ Gahche, PE Miller, KW Dodd, CT Sempos, and DM Murray, no conflicts of interest.
Similar articles
-
Multivitamin use and cardiovascular disease in a prospective study of women.Am J Clin Nutr. 2015 Jan;101(1):144-52. doi: 10.3945/ajcn.114.088310. Epub 2014 Nov 5. Am J Clin Nutr. 2015. PMID: 25527758 Free PMC article. Clinical Trial.
-
Multivitamin Use and the Risk of Cardiovascular Disease in Men.J Nutr. 2016 Jun;146(6):1235-40. doi: 10.3945/jn.115.227884. Epub 2016 Apr 27. J Nutr. 2016. PMID: 27121531 Free PMC article. Clinical Trial.
-
Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis.Circ Cardiovasc Qual Outcomes. 2018 Jul;11(7):e004224. doi: 10.1161/CIRCOUTCOMES.117.004224. Circ Cardiovasc Qual Outcomes. 2018. PMID: 29991644
-
Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials.Crit Rev Food Sci Nutr. 2015;55(14):1968-91. doi: 10.1080/10408398.2014.912199. Crit Rev Food Sci Nutr. 2015. PMID: 24941429 Review.
-
A systematic review of multivitamin-multimineral use and cardiovascular disease and cancer incidence and total mortality.J Am Coll Nutr. 2013;32(5):339-54. doi: 10.1080/07315724.2013.839909. J Am Coll Nutr. 2013. PMID: 24219377 Review.
Cited by 15 articles
-
Multivitamin/mineral supplementation and the risk of cardiovascular disease: a large prospective study using UK Biobank data.Eur J Nutr. 2022 Mar 18. doi: 10.1007/s00394-022-02865-4. Online ahead of print. Eur J Nutr. 2022. PMID: 35301588
-
Comparison of 4 Methods to Assess the Prevalence of Use and Estimates of Nutrient Intakes from Dietary Supplements among US Adults.J Nutr. 2020 Apr 1;150(4):884-893. doi: 10.1093/jn/nxz306. J Nutr. 2020. PMID: 31851315 Free PMC article.
-
Predictors of toxic metal exposures among US women of reproductive age.J Expo Sci Environ Epidemiol. 2019 Sep;29(5):597-612. doi: 10.1038/s41370-019-0152-3. Epub 2019 Jun 24. J Expo Sci Environ Epidemiol. 2019. PMID: 31235790 Free PMC article.
-
Federal Monitoring of Dietary Supplement Use in the Resident, Civilian, Noninstitutionalized US Population, National Health and Nutrition Examination Survey.J Nutr. 2018 Aug;148(Suppl 2):1436S-1444S. doi: 10.1093/jn/nxy093. Epub 2018 Aug 3. J Nutr. 2018. PMID: 31105335 Free PMC article. Review.
-
The balance between food and dietary supplements in the general population.Proc Nutr Soc. 2019 Feb;78(1):97-109. doi: 10.1017/S0029665118002525. Epub 2018 Oct 30. Proc Nutr Soc. 2019. PMID: 30375305 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical